胞质DNA的出现通常会触发天然免疫应答，但细胞同时必须避免将自身来源的DNA误识别为危险信号。维持这一平衡对于限制慢性炎症、自身免疫及相关病理过程至关重要。TREX1是这一过程中的关键核酸酶，长期以来被认为主要通过降解胞质DNA来抑制cGAS-STI ...

重磅消息：自2026年初起，Cell Symposia正式更名为Cell Press Symposia。此次焕新，彰显Cell ...

Dendritic cells (DCs) have emerged in the field of cancer immunotherapy as the most potent professional antigen-presenting ...

Silencing mRNA expression in dendritic cells did not impair T‑cell priming, including for SARS‑CoV‑2 antigens, suggesting that cross‑presentation by other cell types is sufficient to initiate immunity ...

该研究揭示了肠道上皮免疫缺陷引起的菌群失调，通过释放特定的微生物代谢产物驱动Th2细胞分化，进而加剧特应性皮炎的完整病理机制，为深入理解“肠-皮轴”免疫病理网络提供了全新的分子视角。

Chimeric antigen receptor-T (CAR-T) cell therapy represents a major breakthrough in cancer immunotherapy, providing remarkable clinical benefits for ...

Macrophages, key regulators of tissue health and immune defense, are among the most abundant immune cells in solid tumors. Their role in cancer has been difficult to define because even closely ...

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children's Research Hospital published today in ...

A study showed that non-immune cells shape mRNA vaccine responses. Expression of mRNA in muscle cells increased immunity, ...

Researchers at Weill Cornell Medicine have discovered that activated T cells release extracellular vesicles carrying immune-related DNA fragments that can enter both immune and tumor cells, enhancing ...