PAX6-dependent epithelial differentiation and developmental trajectories of the ocular surface are elucidated through single-cell RNA sequencing of hiPSC-derived ocular organoids. This study provides ...

Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human brain development before birth—a resource that resolves longstanding ...

Scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why ...

A recent Nature study evaluates post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells (ESCs). Study: Complete human day 14 ...

Researchers have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four weeks after fertilization. This is ...

Embryonic development, also known as embryogenesis, is a cornerstone in understanding the origins of life. But studying this marvel of intricate and layered biological processes in people faces ...

Animal models continue to be a mainstay of basic research and preclinical studies. But since animals such as mice only approximate humans, they may generate findings of limited clinical relevance.