Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors ...

Chimeric antigen receptor-T (CAR-T) cell therapy represents a major breakthrough in cancer immunotherapy, providing remarkable clinical benefits for ...

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells ...

Overall, the findings demonstrate how mitochondrial respiration is required for T-cell proliferation and memory formation, which may help inform the development of new therapeutic strategies that ...

Additionally, they found that impaired mitochondrial complex III function reduced CD8 + T-cell memory formation, which helps the immune cells persist after initial infection and provide protection for ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Commercialization ready compound supports a new method of generating highly functional human CAR-T cells for treating infectious diseases and cancer In experimental models, human CAR-T cells ...

Phase 1 Clinical Trial of EVOLVE104 Continues to Advance According to PlanOral Minisymposium Presentation Demonstrates That EVOLVE T Cell ...